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inglés al español: Regulation of energy substrate metabolism in the diabetic heart Detailed field: Medicina: Cardiología
Texto de origen - inglés Regulation of energy substrate metabolism in the diabetic heart
Stanley WC, Lopaschuk GD. McCormack JG.
It has been recognized for many years that diabetic patients have a significantly greater incidence and severity of angina, acute myocardial infarction, and congestive heart failure, compared with nondiabetic patients. Although an increased incidence of atherosclerosis in diabetics contributes to these complications, population-based studies have shown that noncoronary factors are also contributory factors.
Abnormalities in myocardial energy metabolism in the diabetic population are probably important contributing factors to this greater mortality. Normal cardiac function is dependent on a constant rate of synthesis of ATP by mitochondrial oxidative phosphorylation and glycolysis. Oxidation of fatty acids is normally responsible for about 60% to 70% of the ATP, with the balance coming from the oxidation of pyruvate derived from glycolisis. This is particularly evident during ischemia, which results in profound disturbances in myocardial substrate utilization, leading to contractile dysfunction.
Diabetic patients, even in the absence of ischemia, have decreased myocardial glucose and lactate uptake and a greater use of free fatty acids and ketone bodies relative to the nondiabetic population.
Accumulation of fatty acids and their toxic intermediaries has been associated with mechanical dysfunction and cell damage in the diabetic heart subjected to ischemia.
Several pharmacological approaches are available to suppress fatty acid oxidation and increase flux through PDH these may directly inhibit the fatty acid pathway or stimulate the glucose pathway. Studies in isolated hearts suggest that such therapies would be of benefit to the diabetic heart during and following myocardial ischemia.
As a result, there is a clear rationale for using metabolic agents to improve contractible function and decrease irreversible damage following myocardial ischemia.
Traducción - español Regulación del metabolismo energético en el corazón de los diabéticos
Stanley WC, Lopaschuk GD. McCormack JG.
Se sabe desde hace muchos años que, comparados con pacientes no diabéticos, los diabéticos tienen una incidencia y una severidad significativamente mayores de angina de pecho, infarto de miocardio e insuficiencia cardiaca congestiva. Aunque una mayor incidencia de ateroesclerosis en los diabéticos contribuye a estas complicaciones, los estudios de población demuestran que los factores no-coronarios también contribuyen.
Probablemente las anormalidades del metabolismo energético del miocardio en la población de diabéticos contribuyen a esta mayor mortalidad. La normalidad de la función del miocardio depende de una tasa constante de síntesis de ATP por los sistemas mitocondriales de fosforilación oxidativa y glicólisis. La oxidación de los ácidos grasos normalmente es responsable de la producción de 60% a 70% del ATP, mientras que el resto proviene de la oxidación del piruvato derivado de la glicólisis. Esto es particularmente evidente durante la isquemia, la que da origen a profundas alteraciones de la utilización de los sustratos por parte del miocardio, llevando a la disfunción de la contractilidad.
En comparación con la población no diabética, los pacientes diabéticos, aun en ausencia de isquemia, tienen disminuida la captación por el miocardio de glucosa y lactato y un uso más intenso de ácidos grasos y cuerpos cetónicos.
La acumulación de ácidos grasos y sus intermediarios tóxicos ha sido asociada con la disfunción mecánica y el daño celular en el corazón diabético sometido a isquemia.
Existen varios enfoques farmacológicos para suprimir la oxidación de los ácidos grasos y aumentar el flujo a través de la PDH; éstas alternativas pueden inhibir directamente la vía de los ácidos grasos o estimular la vía de la glucosa. Los estudios realizados en el corazón aislado sugieren que dichas terapéuticas serían beneficiosas para el corazón diabético durante y después de la isquemia del miocardio.
Como resultado, hay un claro fundamento para usar agentes metabólicos que mejoren la función contráctil y disminuyan el daño irreversible después de la isquemia del miocardio.
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Años de experiencia: 35 Registrado en ProZ.com: Sep 2006
inglés al español (National Accreditation Authority for Translators and Interpreters) español al inglés (Colegio de Traductores de la Provincia de córdoba) inglés al español (Colegio de Traductores de la Povincia de Córdoba)
Miembro de
National Accreditation Authority for Translators and Interpreter, CTPPC
Software
Adobe Acrobat, Adobe Photoshop, Microsoft Excel, Microsoft Word, MS PowerPoint, SDLX, Trados Studio, Wordfast
I am a professional Translator graduated from the Facultad de Lenguas of the Universidad Nacional de Córdoba (Argentina) with over 17 years experience in EN>ES and ES>EN translation in Biomedical Sciences and Law. I have worked for 2 years as in-house translator for the Bureau of Rural Sciences of Australia and am presently in-house translator for VisAustralia Inc.
Especialización 
CV/Resume (DOC)