This site uses cookies. Some of these cookies are essential to the operation of the site, while others help to improve your experience by providing insights into how the site is being used. For more information, please see the ProZ.com privacy policy.
Cookie settings
tributaria (please read question)
hacer" extras"
This question was closed without grading. Reason: Answer found elsewhere
Jun 19, 2009 05:29
14 yrs ago
9 viewers *
Spanish term

progresión a temozolamida

Spanish to English Medical Medical (general) oncology
Lima: progress notes: patient with astrocytoma: "Paciente se ha perdido de vista sin reevaluación de enfermedad por lo que no podemos asegurar progresión a temozolamida." AND "Se explica pronóstico de enfermedad, no se puede asegurar que exista Progresión a temozolamida por lo regular del tto, sin embargo familiar insiste en continuar dicho fármaco, refiere que traerá feches durante las cuales tomó el medicamento." Many thanks for an explanation of "progresión a temozolamida"...
Proposed translations (English)
5 +1 add temozolomide (to the current therapy) to replace...
3 +1 progression/progressed on/during/following termozolomide therapy/treatment >>> in terms of progressi

Discussion

Alvaro Aliaga Jun 27, 2009:
What was the answer? Hello Lesley:
I have seen this expression many times and that why I insist with the phrase I proposed. Once again, I think the source text is pretty dodgy and words like "regular" instead of "irregular" tell me that this is one of those cases where the best thing you can do is translating based strictly on what you see and making notes to the client saying that it doesn't make much sense but as translators we can't imagine how it should read.
In any case, could you please share the answer you finally chose? It would be very interesting to see how you or the client solved this riddle.
Thank you very much.
Lesley Jackson (X) (asker) Jun 22, 2009:
I think the first quoted sentence may mean "we cannot be certain of his reponse to temozolamide," and the second means "we cannot be certain that there has been a good response [i.e., progress] to temozolamide due to the irregularity of treatment." LJ
Lesley Jackson (X) (asker) Jun 22, 2009:
But surely the meaning is not the same, brainfloss... a patient cannot progress to temozolamide, in the sense you described, if he's already taking it. I'm thinking the sense of "progresión a temozolomida" must be something like "continuation of..." or - as Libe suggested - that the doctors cannot assure that patient will progress on temozolomide (or assure that it is having the desired effect) if he takes it so irregularly and doesn't come in for follow-ups. In any case, I don't think it can be "progress to" because he's already been taking it. LJ
Alvaro Aliaga Jun 21, 2009:
Definitely! I did forget to mention that, it should have been "no se puede asegurar que exista "progresión a temozolamida por lo IRREGULAR del tto" from the beginning. Well, in my eyes the meaning is still the same, my answer doesn't change though the sentences read weird.
Lesley Jackson (X) (asker) Jun 21, 2009:
shedding light... Context I should have mentioned for the sentences I quoted: pt was somehow getting and taking the Temodal even though not coming in for checkups. I think there's a transcription error in the one sentence -- I think it should say "lo irregular del tto" because the problem was that he was taking the drug but they didn't know exactly when (so his mother was going to provide dates). Given this, any new thoughts on the meaning of "no se puede asegurar que exista..." ? Thanks.
Alvaro Aliaga Jun 19, 2009:
Cuidado El original aunque no sea de la mejor calidad claramente dice "progresión A temozolamida" y no "progresión CON temozolamida" lo cual resulta en una enorme diferencia ya que evidentemente habla del tratamiento y no de la evolución clínica del paciente.
hedapen Jun 19, 2009:
antecedentes Hola Lesley, he mirado un poquito los antecedentes para intentar interpretar esas notas.
Los astrocitomas son un grupo de neoplasias intracraneales primarios del sistema nervioso central que aparecen en el parenquima cerebral y rara vez produce metástasis a otros tejidos. El tratamiento de los gliomas es únicamente paliativo y sólo consigue alargar algunos meses la supervivencia. La temozolamida ha sido aprobada en la Unión Europea para el tratamiento de pacientes con glioma maligno, La temozolamida es un agente alquilante quyo mecanismo de acción consiste en inhibir la replicación del DNA.Se ha demostrado que el fármaco es activo frente a los gliomas malignos humanos cuando se administra por vía oral a la dosis de 200 mg/m2 una vez
al día durante 5 días, repitiendo el ciclo cada 28 días.
En tus notas eso de que "el paciente se ha perdido de vista sin reevaluación de enfermedad" hace pensar que no ha vuelto por la consulta médica y no pueden evaluar la evolución del tratamiento (progresión) con la temozolamida y que hay un familiar que quiere que siga haciendo el tratamiento ¿por qué no aparece el paciente?

Proposed translations

+1
2 hrs

progression/progressed on/during/following termozolomide therapy/treatment >>> in terms of progressi

Declined
Adding Temozolomide to Radiotherapy May Improve Survival in... - [ Traducir esta página ] Temozolomide also produced superior results in terms of progression-free ... for 0.25 category 1 credit(s) toward the AMA Physician's Recognition Award. ...
medgenmed.medscape.com/.../501196_print - En caché - Páginas similares
Metastatic melanoma - Skin disorders - Clinical Evidence 22 Aug 2008 ... Dacarbazine compared with temozolomide Dacarbazine is less effective at increasing median progression-free survival rates, but not overall ...
clinicalevidence.bmj.com/ceweb/conditions/.../1718_I3.jsp - Páginas similares
de J Larkin - Artículos relacionados - Las 4 versiones

Annals of Oncology - Fulltext: Volume 13() 2002 p 30 ORAL ... - [ Traducir esta página ] ORAL TEMOZOLAMIDE AS A SAFE AND ACTIVE TREATMENT OF NSCLC BRAIN RECURRENCES THAT PROGRESSED AFTER WHOLE-BRAIN RADIOTHERAPY ...
pt.wkhealth.com/.../fulltext.00002352-200200003-00114.htm - Páginas similares
de R Bordonaro - 2002
Nature Clinical Practice Neurology | Drug Insight: temozolomide as ... - [ Traducir esta página ] Four patients stabilized and 17 progressed despite temozolomide. Median survival for responding patients was 12 months. A similar study conducted by Gilbert ...
www.nature.com/ncpneuro/journal/.../ncpneuro0045.html - Páginas similares
de WP Mason - 2005 - Citado por 12 - Artículos relacionados - Las 3 versiones
A Study of XL765 in Combination With Temozolomide in Adults With ... - [ Traducir esta página ] 20 Jun 2008 ... Progressed while on temozolomide. Restriction of some therapies/medications within specific timeframes prior to enrollment and during the ...
clinicaltrials.gov/ct2/show/NCT00704080 - En caché - Páginas similares
Vorinostat and Temozolomide in Treating Patients With Malignant ... - [ Traducir esta página ] 20 Dec 2005 ... Stable disease or progression after radiation therapy (except if they have progressed on temozolomide therapy) OR recurrent disease after ...
clinicaltrials.gov/ct2/show/NCT00268385 - En caché - Páginas similares
Más resultados de clinicaltrials.gov »
Phase II Study of Protracted Daily Temozolomide for Low-Grade ... In recent studies of patients with glioblastoma treated with temozolomide, those tumors that progressed during temozolomide treatment had loss of the ...
clincancerres.aacrjournals.org/cgi/content/full/15/1/330 - Páginas similares
de S Kesari - 2009 - Artículos relacionados
Phase II study of temozolomide in heavily pretreated cancer ... - [ Traducir esta página ] progressed and one patient was classi¢ed as having possibly progressed following temozolomide treatment. Within the entire population of 27 treated patients ...
www.springerlink.com/index/QV2016887U074J54.pdf - Páginas similares
de C Christodoulou - 2001 - Citado por 101 - Artículos relacionados
Temozolomide - [ Traducir esta página ] All patients had previously progressed on prior temozolomide and radiation. The 2 primary endpoints of the study were objective response rate (defined as a ...
www.mongabay.com/.../Temozolomide.html - En caché - Páginas similares
Peer comment(s):
agree Omar Lima Quintana
2 hrs
Gracias Omar
Something went wrong...
+1
3 hrs

add temozolomide (to the current therapy) to replace...

Declined
Hello Lesley:
To answer your question "progresión a temozolamida" means that you have a patient currently receiving a specific treatment for a particular condition, and at some point in the future temozolomide will be added to the therapy usually because any other medication that they have been using did not help as expected to control the condition. It is almost like moving from tier 1 to tier 2 when temozolamida is going to replace the other drug. As you see it's easier to explain the meaning than trying to come up with a short sentece to convey the idea, sorta. I hope this helps
Peer comment(s):
agree liz askew
1 hr
Thank you Liz.
Something went wrong...
Close search
Term search
  • All of ProZ.com
  • Term search
  • Jobs
  • Forums
  • Multiple search