English to Indonesian: Comparisons of the tolerability and sensitivity of quetiapine-XR in the acute treatment of schizophrenia, bipolar mania, bipolar depression, major depressive disorder and generalized anxiety disorder
General field: Medical
Detailed field: Medical (general) | |
Source text - English
Quetiapine extended-release (quetiapine-XR) has been studied in patients with schizophrenia, bipolar mania, bipolar depression, major depressive disorder (MDD) and generalized anxiety disorder (GAD). The purpose of this study was to compare the tolerability and sensitivity of quetiapine-XR among these psychiatric conditions. The discontinuation due to adverse events (DAEs) and reported somnolence in randomized, double-blind, placebo-controlled studies of quetiapine-XR in these psychiatric condition were examined. The absolute risk reduction or increase and the number needed to treat to benefit (NNTB) or harm (NNTH) for DAEs and reported somnolence of quetiapine-XR more than 300 mg/d relative to placebo were estimated. | Translation - Indonesian
Quetiapine lepas lambat telah dipelajari pada pasien penderita skizofrenia, mania bipolar, depresi bipolar, gangguan depresi mayor, dan gangguan kecemasan umum. Tujuan penelitian ini adalah untuk membandingkan tolerabilitas dan sensitivitas quetiapine lepas lambat pada gangguan - gangguan psikiatris tersebut di atas. Penghentian obat ini karena adanya reaksi yang tidak diinginkan dan laporan somnolens diketahui pada penelitian acak, samar ganda, kontrol plasebo quetiapine-XR pada gangguan - gangguan psikiatris ini. Peningkatan atau pengurangan risiko absolut dan jumlah yang diperlukan untuk terapi untuk menguntungkan atau merugikan pada reaksi yang tidak diinginkan dan somnolens yang dilaporkan dari quetiapine-XR lebih dari 300 mg/hari relative to placebo telah diperkirakan |
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