English to Chinese: Peripheral Nerve Regeneration by Microbraided Poly(L-lactide-co-glycolide) Biodegradable Polymer Fibers General field: Other Detailed field: Textiles / Clothing / Fashion | |
Source text - English Tiny tubes with fiber architecture were developed by a novel method of fabrication upon introducing some modification to the microbraiding technique, to function as nerve guide conduit and the feasibility of in vivo nerve regeneration was investigated through several of these conduits. Poly(L-lactide-co-glycolide) (10:90) polymer fibers being biocompatible and biodegradable were used for the fabrication of the conduits. The microbraided nerve guide conduits (MNGCs) were characterized using scanning electron microscopy to study the surface morphology and fiber arrangement. Degradation tests were performed and the micrographs of the conduit showed that the degradation of the conduit is by fiber breakage indicating bulk hydrolysis of the polymer. Biological performances of the conduits were examined in the rat sciatic nerve model with a 12-mm gap. After implantation of the MNGC to the right sciatic nerve of the rat, there was no inflammatory response. One week after implantation, a thin tissue capsule was formed on the outer surface of the conduit, indicating good biological response of the conduit. Fibrin matrix cable formation was seen inside the MNGC after 1 week implantation. One month after implantation, 9 of 10 rats showed successful nerve regeneration. None of the implanted tubes showed tube breakage. The MNGCs were flexible, permeable, and showed no swelling apart from its other advantages. Thus, these new poly(L-lactide-co-glycolide) microbraided conduits can be effective aids for nerve regeneration and repair and may lead to clinical applications. | Translation - Chinese 以纖維結構來製管是為一新製造方法,對於微編織技術提出修改使其成為神經導管並進行體內神經再生的可行性之研究。poly(L-lactide-co-glycolide)(PLGA)(10:90)聚合物纖維為生物相容性和生物可降解性被用於製成導管。利用掃描電子顯微鏡進行微編織神經導管(MNGCs)的表徵、表面形貌和纖維分布觀察。降解試驗和顯微照片進行導管觀察,聚合物的水解使纖維斷裂而導管被降解掉。以大鼠坐骨神經為12 mm的斷裂差距檢測導管的生物性能。植入MNGC於右側坐骨神經的大鼠後,沒有炎症反應。植入後一個星期,薄組織膠囊在外表面的導管形成,顯示了導管的良好生物反應。MNGC植入後1週,看到裡面形成纖維蛋白基質束。植入後1個月,10隻中有9隻老鼠表明神經再生成功。沒有植入管是有斷裂的情形。MNGCs的優點是靈活的,透氣的,無明顯腫脹。因此,這些新的PLGA微編織導管可以有效增加的神經再生和修復,並增加在臨床應用上的價值。
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