O-グルクロン酸抱合代謝物由来

English translation: from O-glucuronidated metabolites

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
Japanese term or phrase:O-グルクロン酸抱合代謝物由来
English translation:from O-glucuronidated metabolites
Entered by: David Patrick

14:37 Sep 7, 2012
Japanese to English translations [PRO]
Medical - Medical: Pharmaceuticals
Japanese term or phrase: O-グルクロン酸抱合代謝物由来
一方,ヒト凍結肝細胞を用いたin vitro代謝試験の結果から,未変化体の他に酸化代謝物,硫酸抱合代謝物,グルタチオン抱合代謝物及びO-グルクロン酸抱合代謝物由来を含む複数のピークが検出されており,本剤の代謝には複数の代謝酵素が関与している可能性が示唆されている。

Thanks.
JpBaugh
United Kingdom
Local time: 09:42
from O-glucuronidated metabolites
Explanation:
I think here the 由来 refers to all items listed previously.
Selected response from:

David Patrick
Ireland
Grading comment
Thanks!
3 KudoZ points were awarded for this answer



Summary of answers provided
3 +2from O-glucuronidated metabolites
David Patrick
3 +1from metabolites...O-glucuronic acid conjugation
chris_k
3o-gluconic acid conjugated metabolite derivative
Christiane Feldmann-Leben


  

Answers


37 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
o-gluconic acid conjugated metabolite derivative


Explanation:
Just a shot. I don't now where you problem lies, so maybe this helps.

Christiane Feldmann-Leben
Germany
Local time: 10:42
Specializes in field
Native speaker of: Native in GermanGerman
Notes to answerer
Asker: Thanks! That's what I was thinking.

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1 hr   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +2
from O-glucuronidated metabolites


Explanation:
I think here the 由来 refers to all items listed previously.

David Patrick
Ireland
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 57
Grading comment
Thanks!
Notes to answerer
Asker: Ah, that's the other possibility I was thinking. So I'm back at square one.


Peer comments on this answer (and responses from the answerer)
agree  Christiane Feldmann-Leben: Well, thinking again, I would agree with this opinion.
20 hrs
  -> Thanks

agree  Balazs Oroszlany: Yes, 由来 refers to all items.
1 day 1 hr
  -> Thank you
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23 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +1
from metabolites...O-glucuronic acid conjugation


Explanation:
I couldn't put what I wanted write for your answer. I would like to say it like this.

multiple peaks from metabolites including oxidation, sulfuric acid conjugation, glutathion conjugation and O-glucuronic acid conjugation,

"detected" would be put in front or at the end, depends how you would make the whole sentence.

I googled hepatocytes in vitro drug metabolism, then put each metabolic pathway such as "glucuronic acid conjugation" and got quite good number of hits talking about your topic.

Good luck !

chris_k
Japan
Local time: 18:42
Native speaker of: Native in JapaneseJapanese
PRO pts in category: 8

Peer comments on this answer (and responses from the answerer)
agree  David Patrick: Though I might word it; "from oxidized metabolites, sulfate conjugated metabolites, glutathione conjugated metabolites and O-glucuronidated metabolites"
2 hrs
  -> thanks ! how would you include "含む" nuance into the sentence though ? that's where I had problem...
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