GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW) | ||||||
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19:53 Jul 13, 2009 |
Italian to English translations [PRO] Medical - Medical: Pharmaceuticals | |||||||
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| Selected response from: texjax DDS PhD Local time: 03:27 | ||||||
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Summary of answers provided | ||||
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3 +5 | pivalic acid |
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Summary of reference entries provided | |||
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carnitine datasheet |
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Discussion entries: 3 | |
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pivalic acid Explanation: Typo for pivalic acid/pivalate, which may cause carnitine deficiency. I have no time to read all the references, but I believe we are on the right track. Sodium pivalate, a compound conjugated to carnitine and excreted in the urine was used to induce a secondary carnitine deficiency. ... jn.nutrition.org/cgi/content/abstract/121/12/2029 - Similar by PB Bianchi - 1991 - Cited by 19 - Related articles - All 4 versions http://www.google.com/search?hl=en&ie=ISO-8859-1&q="secondar... Prodrugs that liberate pivalate (trimethylacetic acid) after hydrolysis have been developed to improve the bioavailability of therapeutic candidates. Catabolism of pivalate released by activation of a prodrug is limited in mammalian tissues. Pivalate can be activated to a coenzyme A thioester in cells. In humans, formation and urinary excretion of pivaloylcarnitine generated from pivaloyl-CoA is the major route of pivalate elimination. Because the total body carnitine pool is limited and can only slowly be replenished through normal diet or biosynthesis, treatment with large doses of pivalate prodrugs may deplete tissue carnitine content. http://pharmrev.aspetjournals.org/cgi/content/full/54/4/589 http://www.chemexper.com/chemicals/supplier/cas/75-98-9.html File Format: PDF/Adobe Acrobat - View as HTML Trattamento con Benzoato, Acido Pivalico, or. Acido Valproico. . Deficienza di Assorbimento di Carnitina. . Deficienza di Biotinidasi ... www.isf-stem.com/documenti/06-080128-Patologie screening.pd... - Similar http://en.wikipedia.org/wiki/Pivalic_acid |
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