acido rivalico

English translation: pivalic acid

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
Italian term or phrase:acido pivalico
English translation:pivalic acid
Entered by: texjax DDS PhD

19:53 Jul 13, 2009
Italian to English translations [PRO]
Medical - Medical: Pharmaceuticals
Italian term or phrase: acido rivalico
"Metaboliti tossici possono formarsi anche in seguito al trattamento con alcuni farmaci (es: acido valproico, antibiotici coniugati con l’acido rivalico). "

All I can find on the internet is pivalic acid. Can anyone suggest an answer with some references to back it up? TIA.
Shera Lyn Parpia
Italy
Local time: 08:27
pivalic acid
Explanation:
Typo for pivalic acid/pivalate, which may cause carnitine deficiency.
I have no time to read all the references, but I believe we are on the right track.

Sodium pivalate, a compound conjugated to carnitine and excreted in the urine was used to induce a secondary carnitine deficiency. ...
jn.nutrition.org/cgi/content/abstract/121/12/2029 - Similar
by PB Bianchi - 1991 - Cited by 19 - Related articles - All 4 versions

http://www.google.com/search?hl=en&ie=ISO-8859-1&q="secondar...

Prodrugs that liberate pivalate (trimethylacetic acid) after hydrolysis have been developed to improve the bioavailability of therapeutic candidates. Catabolism of pivalate released by activation of a prodrug is limited in mammalian tissues. Pivalate can be activated to a coenzyme A thioester in cells. In humans, formation and urinary excretion of pivaloylcarnitine generated from pivaloyl-CoA is the major route of pivalate elimination. Because the total body carnitine pool is limited and can only slowly be replenished through normal diet or biosynthesis, treatment with large doses of pivalate prodrugs may deplete tissue carnitine content.

http://pharmrev.aspetjournals.org/cgi/content/full/54/4/589

http://www.chemexper.com/chemicals/supplier/cas/75-98-9.html

File Format: PDF/Adobe Acrobat - View as HTML
Trattamento con Benzoato, Acido Pivalico, or. Acido Valproico. . Deficienza di Assorbimento di Carnitina. . Deficienza di Biotinidasi ...
www.isf-stem.com/documenti/06-080128-Patologie screening.pd... - Similar

http://en.wikipedia.org/wiki/Pivalic_acid

Selected response from:

texjax DDS PhD
Local time: 03:27
Grading comment
thanks!
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +5pivalic acid
texjax DDS PhD
Summary of reference entries provided
carnitine datasheet
Dr Lofthouse

Discussion entries: 3





  

Answers


1 hr   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +5
pivalic acid


Explanation:
Typo for pivalic acid/pivalate, which may cause carnitine deficiency.
I have no time to read all the references, but I believe we are on the right track.

Sodium pivalate, a compound conjugated to carnitine and excreted in the urine was used to induce a secondary carnitine deficiency. ...
jn.nutrition.org/cgi/content/abstract/121/12/2029 - Similar
by PB Bianchi - 1991 - Cited by 19 - Related articles - All 4 versions

http://www.google.com/search?hl=en&ie=ISO-8859-1&q="secondar...

Prodrugs that liberate pivalate (trimethylacetic acid) after hydrolysis have been developed to improve the bioavailability of therapeutic candidates. Catabolism of pivalate released by activation of a prodrug is limited in mammalian tissues. Pivalate can be activated to a coenzyme A thioester in cells. In humans, formation and urinary excretion of pivaloylcarnitine generated from pivaloyl-CoA is the major route of pivalate elimination. Because the total body carnitine pool is limited and can only slowly be replenished through normal diet or biosynthesis, treatment with large doses of pivalate prodrugs may deplete tissue carnitine content.

http://pharmrev.aspetjournals.org/cgi/content/full/54/4/589

http://www.chemexper.com/chemicals/supplier/cas/75-98-9.html

File Format: PDF/Adobe Acrobat - View as HTML
Trattamento con Benzoato, Acido Pivalico, or. Acido Valproico. . Deficienza di Assorbimento di Carnitina. . Deficienza di Biotinidasi ...
www.isf-stem.com/documenti/06-080128-Patologie screening.pd... - Similar

http://en.wikipedia.org/wiki/Pivalic_acid



texjax DDS PhD
Local time: 03:27
Meets criteria
Specializes in field
Native speaker of: Native in ItalianItalian
PRO pts in category: 202
Grading comment
thanks!
Notes to answerer
Asker: Thanks, this is exactly what I needed - the funny thing is that there are several Italian links to acido rivalico, such as this one www.bioinst.com/pdf/istruzioni_raccolta_stepone.pdf as well as to acido pivalico.


Peer comments on this answer (and responses from the answerer)
agree  Lirka: most probably
39 mins
  -> Thank you Lirka

agree  Zareh Darakjian Ph.D.: Yes. Antibiotics that are conjugated with pivalic acid release the latter, I believe in the intestinal wall... // Nice to see you too Doctor!
46 mins
  -> Thanks Zareh, nice to see you here

agree  Dr Lofthouse: agree - its a typo for 'pivalico' - refers to pivaloyl antibiotics like pivampicillin'
3 hrs
  -> Grazie Dr Loft :)

agree  Panagiotis Andrias (X)
10 hrs
  -> Thanks

agree  Lionel_M (X)
13 hrs
  -> Grazie 1000 Lionel
Login to enter a peer comment (or grade)




Reference comments


4 hrs
Reference: carnitine datasheet

Reference information:
mentions 'pivaloyl antibiotics'


    Reference: http://www.chm.bris.ac.uk/motm/carnitine/Carnitine.htm
Dr Lofthouse
France
Does not meet criteria
Works in field
Native speaker of: Native in EnglishEnglish, Native in ItalianItalian
PRO pts in category: 28
Login to enter a peer comment (or grade)



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