βασιζόμενη στο β-λακταμικό δακτύλιο

English translation: β-lactam ring

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
Greek term or phrase:β-λακταμικός δακτύλιος
English translation:β-lactam ring
Entered by: Natassa Iosifidou

11:42 Apr 14, 2004
Greek to English translations [PRO]
Medical - Medical: Pharmaceuticals
Greek term or phrase: βασιζόμενη στο β-λακταμικό δακτύλιο
Η δράση της γενικά συγκρίνεται με αυτή των πενικιλλινών, βασιζόμενη στο β-λακταμικό δακτύλιο
Having trouble with 2nd part of sentence
All help much appreciated
roguestate
Local time: 16:03
based on the β-lactam ring
Explanation:
Πιστεύω ότι η σωστότερη απόδοση είναι το "β-lactam ring".
Έτσι το συνάντησα σε παλαιότερη μετάφραση που έκανα για την αμοξυκιλλίνη.

Κάνε μια αναζήτηση στο Διαδίκτυο για το "β-lactam ring" και θα βρεις πολλές πηγές.


**β-Lactam** is an enchanted ring which has received enormous attention las t one-half a century as being an essential structural constituent of th erapeutically invaluable antibiotics such as penicillins and cephalospo rins. These antibiotics are known to manifest their antimicrobial acti vity via inhibition of the enzymic activity of D-alanyl-D-alanine transpeptidase which plays a critical role in the process o f bacterial cell wall formation.^{1,2} This enzyme inactivating property i s attributed to the β-lactam ring present in the antibiotic molecules.^{1,2} However, wide spread uses of these antibiotics have led to emergenc es of resistant strains. These resistant bacterial strains produce enzymes (β-lactamases) which catalyze the hydrolysis of β-lactam moiety in the antibio tics, thus rendering them to be ineffective as antibacterials.^{3} Recent ly, β-lactam derivatives have also been studied as inhibitors of human leukocyte elastase whose aberrant activity is implicated to causes seve ral pulmonary diseases such as emphysema and cystic fibrocis.^{4}
http://journal.kcsnet.or.kr/publi/bul/bu96n1/bu96n1t11.html


β-lactam antibiotics like penicillins and cephalosporins are the most frequently used drugs for the treatment of serious bacterial infections. β-lactamase production is the major mechanism of bacterial resistance to β-lactams. These enzymes hydrolyse the **β-lactam ring** and hence inactivate the antibiotics before they reach their target site, the penicillin-binding proteins (PBPs). Gram-negative bacteria produce the β-lactamase either constitutivly or after induction by β-lactam antibiotics.>>
http://www.ifmb.uni-bonn.de/wiedemann2e.htm

Many antibiotics from the cephalosporin and penicillin family contain a **β-lactam ring**. Some of these are produced directly by fermentation, but other sub-families including the carbapenems are produced by total synthesis. Because total synthesis is extremely expensive, the production costs have a significant impact on price and this limits the use of antibiotics produced in this manner.
http://www.isis-innovation.com/licensing/1167.html

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Note added at 2004-04-14 12:33:14 (GMT)
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β-Lactam-Antibiotica, -tika

engl.: β-lactam antibiotics

die Synthese der Bakterien-Zellwand hemmende Stoffe mit einem **β-Lactam-Ring**, der die antimikrobielle Aktivität bewirkt; Vertreter: Penicilline (dort Formel), Cephalosporine, Carbapeneme u. Monobactame.

http://www.gesundheit.de/roche/ro20000/r21481.html
Selected response from:

Natassa Iosifidou
Greece
Local time: 16:03
Grading comment
Thanks a lot everyone!!
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +3based on β-lactamic ring
Theodoros Linardos
5 +2based on the β-lactam ring
Natassa Iosifidou
4as it is based on the b-lactamic ring
sassa


  

Answers


10 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +3
based on β-lactamic ring


Explanation:
... chain is joined to the β-lactamic ring in the trans position (Fig. 2). The cases in the literature of cross reactivity of imipenem and penicillin suggest that


    joh.med.uoeh-u.ac.jp/pdf/E42/E42_6_10.pdf
Theodoros Linardos
Germany
Local time: 15:03
Native speaker of: Greek

Peer comments on this answer (and responses from the answerer)
agree  Vicky Papaprodromou
6 mins

agree  Calliope Sofianopoulos (X): I also saw your version of it. I'm afraid I can't say which is the most correct form of the term. They obviously mean the same thing.
8 mins

agree  Evdoxia R. (X)
26 mins
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13 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
βασιζόμενη στο β-λακταμικό δακτύλιο
as it is based on the b-lactamic ring


Explanation:
"βασιζόμενη" denotes reason.
It is compared to that of penicillin, because it is based on the b-lactamic ring.

] FULL PAPER
Είδος αρχείου: PDF/Adobe Acrobat
... The vicinal coupling constants of the two protons (H4 in the b-lactamic ring, hydrogen
a to the nitrogen in the six- membered ring) located at the single bond ...
doi.wiley.com/10.1002/chem.200304712

sassa
Native speaker of: Native in GreekGreek, Native in SpanishSpanish
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48 mins   confidence: Answerer confidence 5/5 peer agreement (net): +2
based on the β-lactam ring


Explanation:
Πιστεύω ότι η σωστότερη απόδοση είναι το "β-lactam ring".
Έτσι το συνάντησα σε παλαιότερη μετάφραση που έκανα για την αμοξυκιλλίνη.

Κάνε μια αναζήτηση στο Διαδίκτυο για το "β-lactam ring" και θα βρεις πολλές πηγές.


**β-Lactam** is an enchanted ring which has received enormous attention las t one-half a century as being an essential structural constituent of th erapeutically invaluable antibiotics such as penicillins and cephalospo rins. These antibiotics are known to manifest their antimicrobial acti vity via inhibition of the enzymic activity of D-alanyl-D-alanine transpeptidase which plays a critical role in the process o f bacterial cell wall formation.^{1,2} This enzyme inactivating property i s attributed to the β-lactam ring present in the antibiotic molecules.^{1,2} However, wide spread uses of these antibiotics have led to emergenc es of resistant strains. These resistant bacterial strains produce enzymes (β-lactamases) which catalyze the hydrolysis of β-lactam moiety in the antibio tics, thus rendering them to be ineffective as antibacterials.^{3} Recent ly, β-lactam derivatives have also been studied as inhibitors of human leukocyte elastase whose aberrant activity is implicated to causes seve ral pulmonary diseases such as emphysema and cystic fibrocis.^{4}
http://journal.kcsnet.or.kr/publi/bul/bu96n1/bu96n1t11.html


β-lactam antibiotics like penicillins and cephalosporins are the most frequently used drugs for the treatment of serious bacterial infections. β-lactamase production is the major mechanism of bacterial resistance to β-lactams. These enzymes hydrolyse the **β-lactam ring** and hence inactivate the antibiotics before they reach their target site, the penicillin-binding proteins (PBPs). Gram-negative bacteria produce the β-lactamase either constitutivly or after induction by β-lactam antibiotics.>>
http://www.ifmb.uni-bonn.de/wiedemann2e.htm

Many antibiotics from the cephalosporin and penicillin family contain a **β-lactam ring**. Some of these are produced directly by fermentation, but other sub-families including the carbapenems are produced by total synthesis. Because total synthesis is extremely expensive, the production costs have a significant impact on price and this limits the use of antibiotics produced in this manner.
http://www.isis-innovation.com/licensing/1167.html

--------------------------------------------------
Note added at 2004-04-14 12:33:14 (GMT)
--------------------------------------------------

β-Lactam-Antibiotica, -tika

engl.: β-lactam antibiotics

die Synthese der Bakterien-Zellwand hemmende Stoffe mit einem **β-Lactam-Ring**, der die antimikrobielle Aktivität bewirkt; Vertreter: Penicilline (dort Formel), Cephalosporine, Carbapeneme u. Monobactame.

http://www.gesundheit.de/roche/ro20000/r21481.html

Natassa Iosifidou
Greece
Local time: 16:03
Specializes in field
Native speaker of: Greek
PRO pts in category: 4
Grading comment
Thanks a lot everyone!!

Peer comments on this answer (and responses from the answerer)
agree  ggrozoma: Yes, "lactam" beats "lactamic" 6770 to 41 on Google. Πιο σωστό φαίνεται το β-lactam (or beta-lactam).
7 hrs
  -> Thanx!

agree  Lamprini Kosma
1 day 8 hrs
  -> :)
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