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patient's enrichment study

German translation: Studie mit selektierten Patientenkollektiven/Patientenpopulationen

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:patient\'s enrichment study
German translation:Studie mit selektierten Patientenkollektiven/Patientenpopulationen
Entered by: Veronika Neuhold

20:48 Oct 18, 2010
English to German translations [PRO]
Medical - Genetics / oncology, sarcomas, chemotherapy, trabectedin
English term or phrase: patient's enrichment study
A retrospective study indicates that a composite signature based on DNA repair profile, including low BRCA1 along with high ERCC1 and/or XPG, identifies a highly sensitive population with highly improved treatment outcome. This signature could be used for **patient’s enrichment studies** in sarcoma and on other malignancies sensitive to trabectedin.
_ _ _

Spricht man hier von einer "Patientenanreicherung"?

Vgl. http://www.zeit.de/zeit-wissen/transkript

Vielen Dank!
Veronika Neuhold
Austria
Local time: 17:28
Studie mit definierten Patientenparametern
Explanation:
eine vorläufige, vorsichtige Lösung, da das nicht mein Gebiet ist:

http://jco.ascopubs.org/content/23/22/4838.full
The analysis of an enrichment study design by Friedlin and Simon1 in this issue of the Journal of Clinical Oncology addresses the critical drug development issue of efficiency. It has long been recognized that it is possible to identify patient subpopulations selected from the general population in which it is more likely to show a drug benefit than it would be in an unselected population. The selection of such populations has been called enrichment2 and ranges from practical, variance-decreasing maneuvers (choosing people likely to stay in study and follow directions, people whose blood pressure remains elevated after a period of observation, or people with stable exercise tests); to pathophysiologic selection of people with potentially responsive disease...

http://www.a-zieger.de/Dateien/Wachkoma/Komastimulation.pdf
In Anbetracht einer notwendigen, verantwortlichen
Qualitätssicherung bei zunehmend reduzierten Ressourcen erscheint eine Multi-Center-Studie mit definierten Patientenparametern, einem standardisierten Assessment [40],
funktionellen, interventionsbegleitenden Evaluationsverfahren (Verhaltensbeoabachtung, Messung vegetativer und elektrokortikaler Potentiale, Video-EEG, fMRT, PET) unter
Anwendung eines adäquaten Forschungsdesigns, welches quantitative und qualitative integriert, dringend erforderlich - zum Wohle der Letzten und Schwächsten.
Selected response from:

Bernhard Sulzer
United States
Local time: 11:28
Grading comment
Danke, Bernhard und Anne!
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +2Studie mit definierten Patientenparametern
Bernhard Sulzer
2weiterführende/vertiefende klinische Studien
Andrea Winzer


Discussion entries: 1





  

Answers


1 hr   confidence: Answerer confidence 2/5Answerer confidence 2/5
weiterführende/vertiefende klinische Studien


Explanation:
Vielleicht liege ich da jetzt völlig daneben, aber ich verstehe es so, dass auf Basis dieser neuen Erkenntnisse weiterführende Studien an Patienten mit Sarkomen usw. durchgeführt werden sollen.

Andrea Winzer
United States
Local time: 11:28
Works in field
Native speaker of: Native in GermanGerman
PRO pts in category: 12
Login to enter a peer comment (or grade)

1 hr   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +2
Studie mit definierten Patientenparametern


Explanation:
eine vorläufige, vorsichtige Lösung, da das nicht mein Gebiet ist:

http://jco.ascopubs.org/content/23/22/4838.full
The analysis of an enrichment study design by Friedlin and Simon1 in this issue of the Journal of Clinical Oncology addresses the critical drug development issue of efficiency. It has long been recognized that it is possible to identify patient subpopulations selected from the general population in which it is more likely to show a drug benefit than it would be in an unselected population. The selection of such populations has been called enrichment2 and ranges from practical, variance-decreasing maneuvers (choosing people likely to stay in study and follow directions, people whose blood pressure remains elevated after a period of observation, or people with stable exercise tests); to pathophysiologic selection of people with potentially responsive disease...

http://www.a-zieger.de/Dateien/Wachkoma/Komastimulation.pdf
In Anbetracht einer notwendigen, verantwortlichen
Qualitätssicherung bei zunehmend reduzierten Ressourcen erscheint eine Multi-Center-Studie mit definierten Patientenparametern, einem standardisierten Assessment [40],
funktionellen, interventionsbegleitenden Evaluationsverfahren (Verhaltensbeoabachtung, Messung vegetativer und elektrokortikaler Potentiale, Video-EEG, fMRT, PET) unter
Anwendung eines adäquaten Forschungsdesigns, welches quantitative und qualitative integriert, dringend erforderlich - zum Wohle der Letzten und Schwächsten.


Bernhard Sulzer
United States
Local time: 11:28
Native speaker of: German
PRO pts in category: 4
Grading comment
Danke, Bernhard und Anne!

Peer comments on this answer (and responses from the answerer)
agree  Anne Schulz: oder "Studie mit selektierten Patientenkollektiven" (pardon: "-populationen")
7 hrs
  -> danke dir, Anne!
agree  Andrea Winzer: Wieder was Neues dazugelernt :)
13 hrs
  -> dankeschön, Andrea!
Login to enter a peer comment (or grade)



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